If you want to understand life, don't think about vibrant, throbbing
gels and oozes, think about information technology.
--- Richard Dawkins, The Blind Watchmaker, 1986,
Norton, p. 112.
The grand Question which every naturalist ought to have before him
when dissecting a whale or classifying a mite, a fungus or an
infusorian is "What are the Laws of Life"
-- Charles Darwin
B Notebook B229
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were invented here!
were invented here!
how DNA gets information!
Sphere packing -
Molecular efficiency -
a measure of biological states
US Patent No. 8,703,734 Issued April 22, 2014,
Ilya Lyakhov, Thomas D. Schneider, and Danielle Needle.
as of 2014 Apr 28.
An important paper was published confirming for the first time
my 70% efficiency discovery:
Analysis of DevR regulated genes in Mycobacterium tuberculosis.
Bandyopadhyay A, Biswas S, Maity AK, Banik SK.
Syst Synth Biol. 2014 Mar;8(1):3-20.
preprint at arxiv.)
They observed that the DevR protein has 66% isothermal efficiency.
as of 2014 Mar 11
Peter K. Rogan.
Rapid and comprehensive identification of prokaryotic organisms.
In this patent Pete Rogan made a clever use of sequence logos.
See figure 2: this is a logo of 16S rRNAs. Pete
used the logo to
chose well conserved parts (into which to put PCR primers)
surrounding less conserved parts (which are different for
Thus the sequence of the fragment obtained can rapidly
identify a bacterial species.
The patent will issue on December 13th as US Pat 8,076,104.
as of 2011 Sep 17.
Keywords for indexing:
70 percent efficiency,
DNA binding site,
fundamental mathematics of biology,
National Cancer Institute,
National Institutes of Health,
T. D. Schneider,
Thomas D. Schneider,
limits of computers,
mathematics of biology,
mathematics of living things,
molecular information theory,
theory of biology,
theory of molecular machines,
what is information theory,
what is information
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